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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HUWE1
All Species:
18.18
Human Site:
T217
Identified Species:
50
UniProt:
Q7Z6Z7
Number Species:
8
Phosphosite Substitution
Charge Score:
-0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q7Z6Z7
NP_113584.3
4374
481891
T217
V
K
I
E
K
R
T
T
S
N
T
L
H
Y
I
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001088987
4374
481661
T217
V
K
I
E
K
R
T
T
S
N
T
L
H
Y
I
Dog
Lupus familis
XP_538052
4375
482124
T217
V
K
I
E
K
R
T
T
S
N
T
L
H
Y
I
Cat
Felis silvestris
Mouse
Mus musculus
Q7TMY8
4377
482644
T217
V
K
I
E
K
R
T
T
S
N
T
L
H
Y
I
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001923899
4360
479137
S217
V
K
V
E
K
K
S
S
S
N
T
L
H
Y
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_573059
5146
556842
M215
A
Q
L
E
I
P
D
M
M
D
L
C
H
T
A
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_500284
4177
465393
K213
T
I
I
V
E
Q
P
K
K
D
E
S
V
G
E
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8GY23
3681
404981
Baker's Yeast
Sacchar. cerevisiae
Q03280
3268
374166
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
99.6
98.7
N.A.
97.7
N.A.
N.A.
N.A.
N.A.
N.A.
81.6
N.A.
33.7
N.A.
26.2
N.A.
Protein Similarity:
100
N.A.
99.7
99.1
N.A.
98.6
N.A.
N.A.
N.A.
N.A.
N.A.
88.4
N.A.
48.4
N.A.
44.3
N.A.
P-Site Identity:
100
N.A.
100
100
N.A.
100
N.A.
N.A.
N.A.
N.A.
N.A.
73.3
N.A.
13.3
N.A.
6.6
N.A.
P-Site Similarity:
100
N.A.
100
100
N.A.
100
N.A.
N.A.
N.A.
N.A.
N.A.
100
N.A.
33.3
N.A.
26.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
24.4
21.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
41.1
38.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
0
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
12
0
0
0
0
0
0
0
0
0
0
0
0
0
12
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
12
0
0
0
% C
% Asp:
0
0
0
0
0
0
12
0
0
23
0
0
0
0
0
% D
% Glu:
0
0
0
67
12
0
0
0
0
0
12
0
0
0
12
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
12
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
67
0
0
% H
% Ile:
0
12
56
0
12
0
0
0
0
0
0
0
0
0
56
% I
% Lys:
0
56
0
0
56
12
0
12
12
0
0
0
0
0
0
% K
% Leu:
0
0
12
0
0
0
0
0
0
0
12
56
0
0
0
% L
% Met:
0
0
0
0
0
0
0
12
12
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
56
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
12
12
0
0
0
0
0
0
0
0
% P
% Gln:
0
12
0
0
0
12
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
45
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
12
12
56
0
0
12
0
0
0
% S
% Thr:
12
0
0
0
0
0
45
45
0
0
56
0
0
12
0
% T
% Val:
56
0
12
12
0
0
0
0
0
0
0
0
12
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
56
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _